Subacute toxicological evaluation of AT‑533 and AT‑533 gel in Sprague‑Dawley rats

As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities in vitro, including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, gel, gel dosage form of AT-533, has been suggested to have anti-keratitis herpes simplex virus type-1 infection-induced effects on the skin lesions animals. However, safety evaluation has, best our knowledge, not examined vivo toxicological tests. Therefore, these tests were carried out present study. A 30-day subacute toxicity test for was conducted at doses 1, 2 4 mg/kg Sprague-Dawley rats, while that using single dose 5 g/kg. The showed high-dose caused lethality side rats. no mortality, loss appetite body weight, adverse reactions, or toxicologically relevant alterations hematology, biochemistry macroscopic findings (except skin) occurred rats exposed low-dose single-dose (5 g/kg) during dermic aforementioned results is non-toxic as shown by except slight irritation, had almost when administered percutaneously 30 days.